Previous UoM President and Vice-Chancellor

Professor of Neuroscience

Understanding the role of immune and inflammatory responses in stroke and vascular dementia

Professor of Neuroscience

Understanding the regulation of inflammation and how it affects disease

Professor of Neuroscience

Investigating the role of inflammation in outcome after stroke and dementia, and understanding how co-morbidity influences this

Professor of Stroke Medicine

Understanding how infection and inflammation contribute to stroke risk, pathophysiology and clinical outcomes after stroke, including post-stroke cognitive decline.

Reader of Neuroscience

Investigation of mechanisms of acute and chronic inflammation, as well as repair process of the brain after CNS injury

Senior Lecturer in Neuroscience

Pre-clinical imaging of blood flow, the blood brain barrier and neuronal activity. Using methods like in-vivo multi-photon imaging, laser speckle imaging and intrinsic optical imaging my lab investigates the early changes during inflammation, ischaemia and neurodegenerative diseases.

Senior Lecturer of Neuroscience

My group is interested in using pre-clinical systems to study disease mechanisms and therapeutic avenues in ICH and stroke

Senior Lecturer in Neuroscience

We develop and apply innovative neuroscience technologies, including wide bandwidth electrophysiology, multi-modal imaging, neuromodulation and gene therapy to study and treat pathological brain activity in a number of neurological disorders including epilepsy, stroke and glioblastoma

Lecturer in Neuroimmunology

My research focuses on translational research to restore microglia functions in age-related neurodegeneration, particularly Alzheimer’s disease. Understanding how microglia metabolism regulates associated neuroinflammation in neurodegenerative diseases. Developing preclinical models for drug testing

Senior Lecturer in Inflammation

Understanding how immune cells sense and respond to danger signals

Investigating neuroimmune interactions and hypothalamic responses during chronic inflammation, and how these interactions shape circadian behaviour (including feeding) and sleep.

Sir Henry Dale Fellow

My lab is focused on using biochemistry, biophysics and in vivo biology to study chemokines, the glycocalyx and inflammatory disease. In particular how chemokines and the glycocalyx barrier collaboratively regulate leukocyte recruitment to the brain.

MRC Career Development Award Fellow

My lab investigates the neuroimmunology of brain injury and disease. We have a special interest in mild traumatic brain injury, often referred to as concussion, from its fundamental immunobiology to neuroimaging in elite athletes

Senior Research Fellow & Senior Experimental Officer

Development and validation of novel neurovascular MRI biomarkers for application in dementia, stroke, and oncology

Stroke Association Lecturer

Thromboinflammation, infection preceding stroke in young adults, novel thrombolytic development

Alzheimer’s Society Future Leaders Fellow

Investigating the role of microglia in frontotemporal dementia and motor neuron disease

BHF Centre of Excellence Transition Fellow

Investigating the impact of intracerebral haemorrhage on cell-cell interactions using intravital imaging strategies

Alzheimer’s Society Future Leaders Fellow

Vascular physiologist trying to elucidate the mechanism behind the reduction in cerebral blood flow in neurodegenerative diseases

Wellcome Trust Career Development Award Fellow

In vivo imaging of neurovascular coupling in Alzheimer’s disease risk and progression

BHF Centre of Excellence Transition Fellow

Elucidating fundamental mechanisms behind how physical and mechanical forces influence inflammatory and immune responses

Sir Robert Boyd Research Fellow

Addressing the cellular mechanisms of NLRP3 regulation in health and disease, including age-related inflammation

Research Programme Manager

Providing strategic and management oversight and support to BIG and the Geoffrey Jefferson Brain Research Centre

Senior Research Technician

Research Technician

My work supports research into the neurovascular mechanisms linking menopause-related vascular changes to increased Alzheimer’s disease risk

Research Technician

Investigating the therapeutic potential of ACE2 enhancement in Alzheimer’s disease

Research Associate

Investigating the molecular mechanisms involved in the regulation of Inflammasomes and inflammatory signalling pathways

Research Associate

Understanding the role of neuroinflammation in cerebral oedema, experimental cerebral malaria and brain tumours

Research Associate

Using intravital imaging to investigate the composition and dynamics of the endothelial glycocalyx in health and disease

Research Associate

Understanding the role of cortical spreading depolarizations in epilepsy, stroke and migraine

Research Associate

Exploring new insights into NLRP3 within inflammatory disease

Research Associate

Investigating the role of cholesterol metabolism in intracerebral haemorrhage

Research Associate

Research Associate

Investigating the role of nanoparticles as drug carriers in in vivo stroke models

Research Associate

Enhancing ACE2 activity with methazolamide as a new way to treat Alzheimer's disease

Research Associate

Understanding the role of perivascular macrophages and oxidative stress in the pathogenesis of stroke

Research Associate

Developing a new tracer to detect amyloid beta in vivo using MRI

Research Associate

Understanding immune and inflammatory changes in the tissue microenvironment in the brain following haemorrhagic stroke

Research Associate

Investigating inflammasome activation in ICH & screening potential inflammasome inhibitors

Research Associate

Investigating inflammasome activation in ICH & screening potential inflammasome inhibitors

Investigating post stroke cognitive impairment and dementia as a result of neurovascular uncoupling in stroke

Investigating the effect of obesity as a comorbidity in stroke, specifically investigating the impairment to the endothelial glycocalyx

Understanding the effects of radiotherapy on the blood brain barrier and how that contributes to cognitive dysfunction

Understanding the mechanisms by which primed mesenchymal stem cells play beneficial roles in hypoxic-ischaemic brain injury

Investigating the association between the peripheral innate immune system and post-stroke cognitive decline

Understanding and targeting AIM2 inflammasome responses in cardiovascular disease

Investigating the role of cholesterol metabolism in modulating the inflammatory response after haemorrhagic stroke

Understanding how neutrophils and thromboinflammatory processes are modulated by caADAMTS13 in intracerebral haemorrhage

Understanding and targeting the regulation of Interleukin-1B secretion, with consideration of the extracellular matrix

Investigating the association between peripheral blood immune status post-stroke and the development of vascular dementia

Characterising the NLRP3 inflammasome response in a zebrafish model of ICH

Investigating ryanodine receptor and BK channel coupling in vascular smooth muscle cells within health and dementia

Researching the cell-specific role of interleukin-1β during cerebrovascular inflammation after stroke

Investigating the association between stroke and Chronic Peripheral Inflammatory Diseases, including inflammatory bowel disease and rheumatoid arthritis

Understanding the role of CNS-macrophage CXCL4 and the extracellular matrix in neuroinflammation

My research focuses on the role that perivascular macrophages, which are macrophages that reside along blood vessels within the brain, have in intracerebral haemorrhage

Investigating peripheral inflammation and its impact on post stroke cognitive decline

Investigating the role of the endothelial glycocalyx in vascular dementia and cerebral small vessel disease

Investigating mechanisms of NLRP3 inflammasome activation in macrophages

Investigating the mechanisms of glymphatic water exchange with MRI-informed biophysical models

Investigating neuroinflammation and blood-brain barrier integrity in frontotemporal dementia and amyotrophic lateral sclerosis

Investigating the effects of intracerebral haemorrhage on myelination using optical imaging of the live mammalian brain

Understanding the mechanisms of brain inflammation and ageing using advanced MRI methods

Investigating the role of infection and B cell immunity in post-stroke cognitive decline

Investigating the mechanisms underlying cognitive impairment associated with medications used to treat seizures in epilepsy

Investigating immune mediated pathways contributing to post-stroke cognitive decline

Developing new acute treatments for ischemic stroke by targeting the cytokine interleukin-1

Investigating the effects and mechanisms of RAS inhibitor treatment on intracerebral haemorrhage

Understanding how different APOE variants alter risk of Alzheimer's disease through the role of microglial ferroptosis

Investigating the influence of inflammation on ischaemic stroke thrombus composition and its importance in the application of novel thrombolytics

Investigating Cerebral Microinfarcts and Vascular Plasticity in a Mouse Model of Hypertension

Developing wireless biocompatible graphene field effect transistors to study infra-slow oscillations in hippocampus of freely moving mice